The study characterized the regime of nutrient leaching under different nitrogen and phosphorus supply of irrigated maize grown as monoculture on Fluvisol for the period 1999-2008 and additionally studied in the years 2009, 2010, and 2011. The aim of the study was to estimate the effect of long-term fertilizer application on the leaching of nutrients from the soil under maize grown as monoculture. The experiment design included four nitrogen fertilizer rates (B1-control, B5, B4, B3, B2) calculated to compensate 50, 75, 100, and 125% from the plant N uptake, respectively. The field plots were equipped with lysimeters (at 50 and 100 cm depth) for studying the relationship between the applied fertilizer rates and the nutrient concentrations in the lysimetric water. The greatest nitrogen concentration in lysimetric water was observed under variant (B3-N200 P150) throughout the study period and the highest N losses were registered (36 kg ha^-1) in 2010 under the same treatment (B3). A very good correlation was found between the N rates, calcium, and magnesium losses. Lysimetric water component compensation shows that agricultural activities have only influenced the speed of weathering and had no significant effect on the rates.