The objective of this research was to determine the effects of moisture content and stalk region on some physical and mechanical properties of safflower stalks. The experiments were conducted at four moisture contents of 9.98, 17.85, 26.37 and 38.75% w.b. and at the bottom, middle and top regions of stalk. The values of the stalk physical properties increased with increasing moisture content. Their values also increased towards the bottom region. The bending stress and Young modulus in bending decreased with increase in the moisture content and increased towards the top regions. The average bending stress values and Young modulus in bending varied between 47.71 and 25.9 MPa and between 2.52 and 1.28 GPa, respectively. The shearing stress and the specific shearing energy increased with increasing moisture content. Their values also increased towards the bottom region of the stalk. The maximum shear stress and specific shearing energy were found to be 7.66 MPa and 33.05 mJ mm-2, respectively, and both occurred at the bottom region with the moisture content of 38.75% w.b.